Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activati...
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Despite decades of research, mechanisms controlling T cell activation remain only partially understood, which hampers T cell-based immune cancer therapies. Here, we performed a genome-wide CRISPR screen to search for genes that regulate T cell activation. Our screen confirmed many of the known regulators in proximal T cell receptor signaling and, i...
Alternative Titles
Full title
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924929
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924929
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1801340115
