PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis
in vivo
, decreases tumour burden and increases survival of mice.
Blocking tumour immunity
Therapeutic antibodies that inhibit the interaction...
Alternative Titles
Full title
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5931375
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5931375
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22396
