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Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5939101

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

About this item

Full title

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.4684-4689

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Lysosomes have an important role in cellular protein and organelle quality control, metabolism, and signaling. On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P₂, which is critical for lysosomal membrane homeostasis during acute osmotic stress and for lysosomal signaling. Here, we identi...

Alternative Titles

Full title

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5939101

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5939101

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1722517115

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