Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
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Author / Creator
Sockolosky, Jonathan T , Trotta, Eleonora , Parisi, Giulia , Picton, Lora , Su, Leon L , Le, Alan C , Chhabra, Akanksha , Silveria, Stephanie L , George, Benson M , King, Indigo C , Tiffany, Matthew R , Jude, Kevin , Sibener, Leah V , Baker, David , Shizuru, Judith A , Ribas, Antoni , Bluestone, Jeffrey A and Garcia, K Christopher
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: The American Association for the Advancement of Science
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Scope and Contents
Contents
Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function, especially for engineered T cells in adoptive cell immunotherapy, but its pleiotropy leads to simultaneous stimulation and suppression of immune responses as well as systemic toxicity, limiting its therapeutic use. We engineered IL-2 cytokine-receptor...
Alternative Titles
Full title
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5947856
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5947856
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aar3246
