PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects
PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Thiazolidinediones (TZDs) are PPARγ agonists with potent insulin-sensitizing effects. However, their use has been curtailed by substantial adverse effects on weight, bone, heart, and hemodynamic balance. TZDs induce the deacetylation of PPARγ on K268 and K293 to cause the browning of white adipocytes. Here, we show that targeted PPARγ mutations res...
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Full title
PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5983311
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5983311
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI98709
