A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal mod...
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
About this item
Full title
Author / Creator
Zhou, Yiming , Castonguay, Philip , Sidhom, Eriene-Heidi , Clark, Abbe R. , Dvela-Levitt, Moran , Kim, Sookyung , Sieber, Jonas , Wieder, Nicolas , Jung, Ji Yong , Andreeva, Svetlana , Reichardt, Jana , Dubois, Frank , Hoffmann, Sigrid C. , Basgen, John M. , Montesinos, Mónica S. , Weins, Astrid , Johnson, Ashley C. , Lander, Eric S. , Garrett, Michael R. , Hopkins, Corey R. and Greka, Anna
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutation...
Alternative Titles
Full title
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
Authors, Artists and Contributors
Author / Creator
Castonguay, Philip
Sidhom, Eriene-Heidi
Clark, Abbe R.
Dvela-Levitt, Moran
Kim, Sookyung
Sieber, Jonas
Wieder, Nicolas
Jung, Ji Yong
Andreeva, Svetlana
Reichardt, Jana
Dubois, Frank
Hoffmann, Sigrid C.
Basgen, John M.
Montesinos, Mónica S.
Weins, Astrid
Johnson, Ashley C.
Lander, Eric S.
Garrett, Michael R.
Hopkins, Corey R.
Greka, Anna
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6014699
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6014699
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aal4178
