Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor ba...
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses. In clinical trials, single doses of BXM profoundly decrease viral titers as well as alleviating influenza symptoms. Here, we characterize the impact...
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Full title
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6018108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6018108
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-27890-4
