UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalyti...
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
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Author / Creator
Gozdecka, Malgorzata , Meduri, Eshwar , Mazan, Milena , Tzelepis, Konstantinos , Dudek, Monika , Knights, Andrew J. , Pardo, Mercedes , Yu, Lu , Choudhary, Jyoti S. , Metzakopian, Emmanouil , Iyer, Vivek , Yun, Haiyang , Park, Naomi , Varela, Ignacio , Bautista, Ruben , Collord, Grace , Dovey, Oliver , Garyfallos, Dimitrios A. , De Braekeleer, Etienne , Kondo, Saki , Cooper, Jonathan , Göttgens, Berthold , Bullinger, Lars , Northcott, Paul A. , Adams, David , Vassiliou, George S. and Huntly, Brian J. P.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a property shared with its catalytically inactive Y-chromosome paralog, UTY (or KDM6C). In keeping with this, we demonstrate concomita...
Alternative Titles
Full title
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
Authors, Artists and Contributors
Author / Creator
Meduri, Eshwar
Mazan, Milena
Tzelepis, Konstantinos
Dudek, Monika
Knights, Andrew J.
Pardo, Mercedes
Yu, Lu
Choudhary, Jyoti S.
Metzakopian, Emmanouil
Iyer, Vivek
Yun, Haiyang
Park, Naomi
Varela, Ignacio
Bautista, Ruben
Collord, Grace
Dovey, Oliver
Garyfallos, Dimitrios A.
De Braekeleer, Etienne
Kondo, Saki
Cooper, Jonathan
Göttgens, Berthold
Bullinger, Lars
Northcott, Paul A.
Adams, David
Vassiliou, George S.
Huntly, Brian J. P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6029661
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6029661
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0114-z
