α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
About this item
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Author / Creator
Atlante, Sandra , Visintin, Alessia , Marini, Elisabetta , Savoia, Matteo , Dianzani, Chiara , Giorgis, Marta , Sürün, Duran , Maione, Federica , Schnütgen, Frank , Farsetti, Antonella , Zeiher, Andreas M. , Bertinaria, Massimo , Giraudo, Enrico , Spallotta, Francesco , Cencioni, Chiara and Gaetano, Carlo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Metastasis formation requires active energy production and is regulated at multiple levels by mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their extreme adaptability and plasticity and facilitates resistance to common anticancer therapies. In spite the potential relevance of a metastasis metabolic control therapy, s...
Alternative Titles
Full title
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6037705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6037705
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-0802-8
