Kank2 activates talin, reduces force transduction across integrins and induces central adhesion form...
Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Integrin-based adhesions play critical roles in cell migration. Talin activates integrins and flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a ‘molecular clutch’ that transmits forces to the extracellular matrix to drive cell migration. Here we identify the evolutionarily conserved Kank protein family as novel compon...
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Full title
Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6053543
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6053543
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3402
