Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer the...
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
About this item
Full title
Author / Creator
Xiao, Tengfei , Li, Wei , Wang, Xiaoqing , Xu, Han , Yang, Jixin , Wu, Qiu , Huang, Ying , Geradts, Joseph , Jiang, Peng , Fei, Teng , Chi, David , Zang, Chongzhi , Liao, Qi , Rennhack, Jonathan , Andrechek, Eran , Li, Nanlin , Detre, Simone , Dowsett, Mitchell , Jeselsohn, Rinath M. , Liu, Shirley and Brown, Myles
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER⁺) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-targeted therapies. Estrogen dir...
Alternative Titles
Full title
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6077722
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6077722
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1722617115
