Senolytics improve physical function and increase lifespan in old age
Senolytics improve physical function and increase lifespan in old age
About this item
Full title
Author / Creator
Xu, Ming , Pirtskhalava, Tamar , Farr, Joshua N. , Weigand, Bettina M. , Palmer, Allyson K. , Weivoda, Megan M. , Inman, Christina L. , Ogrodnik, Mikolaj B. , Hachfeld, Christine M. , Fraser, Daniel G. , Onken, Jennifer L. , Johnson, Kurt O. , Verzosa, Grace C. , Langhi, Larissa G. P. , Weigl, Moritz , Giorgadze, Nino , LeBrasseur, Nathan K. , Miller, Jordan D. , Jurk, Diana , Singh, Ravinder J. , Allison, David B. , Ejima, Keisuke , Hubbard, Gene B. , Ikeno, Yuji , Cubro, Hajrunisa , Garovic, Vesna D. , Hou, Xiaonan , Weroha, S. John , Robbins, Paul D. , Niedernhofer, Laura J. , Khosla, Sundeep , Tchkonia, Tamara and Kirkland, James L.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear. Here we demonstrate that tran...
Alternative Titles
Full title
Senolytics improve physical function and increase lifespan in old age
Authors, Artists and Contributors
Author / Creator
Pirtskhalava, Tamar
Farr, Joshua N.
Weigand, Bettina M.
Palmer, Allyson K.
Weivoda, Megan M.
Inman, Christina L.
Ogrodnik, Mikolaj B.
Hachfeld, Christine M.
Fraser, Daniel G.
Onken, Jennifer L.
Johnson, Kurt O.
Verzosa, Grace C.
Langhi, Larissa G. P.
Weigl, Moritz
Giorgadze, Nino
LeBrasseur, Nathan K.
Miller, Jordan D.
Jurk, Diana
Singh, Ravinder J.
Allison, David B.
Ejima, Keisuke
Hubbard, Gene B.
Ikeno, Yuji
Cubro, Hajrunisa
Garovic, Vesna D.
Hou, Xiaonan
Weroha, S. John
Robbins, Paul D.
Niedernhofer, Laura J.
Khosla, Sundeep
Tchkonia, Tamara
Kirkland, James L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6082705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6082705
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0092-9
