Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
About this item
Full title
Author / Creator
Publisher
New York: Springer New York
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the liver lowers hyperglycemia.
Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also...
Alternative Titles
Full title
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6089616
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6089616
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4514
