Epigenetic regulation of brain region-specific microglia clearance activity
Epigenetic regulation of brain region-specific microglia clearance activity
About this item
Full title
Author / Creator
Ayata, Pinar , Badimon, Ana , Strasburger, Hayley J. , Duff, Mary Kaye , Montgomery, Sarah E. , Loh, Yong-Hwee E. , Ebert, Anja , Pimenova, Anna A. , Ramirez, Brianna R. , Chan, Andrew T. , Sullivan, Josefa M. , Purushothaman, Immanuel , Scarpa, Joseph R. , Goate, Alison M. , Busslinger, Meinrad , Shen, Li , Losic, Bojan and Schaefer, Anne
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried out by microglia, the resident myeloid cells of the brain. Here we show that microglia clearance activity in the adult brain is regionally regulated and depends on the rate of neuronal attrition. Cerebellar, but not striatal or cortical, microglia exhibited hi...
Alternative Titles
Full title
Epigenetic regulation of brain region-specific microglia clearance activity
Authors, Artists and Contributors
Author / Creator
Badimon, Ana
Strasburger, Hayley J.
Duff, Mary Kaye
Montgomery, Sarah E.
Loh, Yong-Hwee E.
Ebert, Anja
Pimenova, Anna A.
Ramirez, Brianna R.
Chan, Andrew T.
Sullivan, Josefa M.
Purushothaman, Immanuel
Scarpa, Joseph R.
Goate, Alison M.
Busslinger, Meinrad
Shen, Li
Losic, Bojan
Schaefer, Anne
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6090564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6090564
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0192-3
