Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expressio...
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
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Author / Creator
Alexandrou, Constantinos , Al-Aqbi, Saif Sattar , Higgins, Jennifer A. , Boyle, William , Karmokar, Ankur , Andreadi, Catherine , Luo, Jin-Li , Moore, David A. , Viskaduraki, Maria , Blades, Matthew , Murray, Graeme I. , Howells, Lynne M. , Thomas, Anne , Brown, Karen , Cheng, Paul N. and Rufini, Alessandro
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy. Here, we show that colorectal cancers (CRCs) display negligible expression of OTC and, in subset of cases, ASS1 proteins. CRC cells fail to grow...
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Full title
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6092409
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6092409
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-30591-7
