Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloi...
Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Intramembrane-cleaving proteases (I-CLiPs) play crucial roles in physiological and pathological processes, such as Alzheimer’s disease and cancer. However, the mechanisms of substrate recognition by I-CLiPs remain poorly understood. The aspartic I-CLiP presenilin is the catalytic subunit of the γ-secretase complex, which releases the amyloid-β pept...
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Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6098081
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6098081
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-30015-6
