Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Arrestins regulate the signaling of ligand-activated, phosphorylated G-protein-coupled receptors (GPCRs). Different patterns of receptor phosphorylation (phosphorylation barcode) can modulate arrestin conformations, resulting in distinct functional outcomes (for example, desensitization, internalization, and downstream signaling). However, the mech...
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Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6101189
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6101189
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-018-0071-3
