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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6121718

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

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Publication information

Publisher

London: Nature Publishing Group UK

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Subjects and topics

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Contents

Somatic mutations in the isocitrate dehydrogenase 2 gene (
IDH2
) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the oncometabolite 2-hydroxyglutarate (2HG)
1
–
8
. Enasidenib (AG-221) is an allosteric inhibitor that binds to the IDH2 dimer interface and blocks the production of 2HG by ID...

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Full title

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6121718

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6121718

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-018-0251-7

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