Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and tr...
Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity
About this item
Full title
Author / Creator
Amodio, Nicola , Stamato, Maria Angelica , Juli, Giada , Morelli, Eugenio , Fulciniti, Mariateresa , Manzoni, Martina , Taiana, Elisa , Agnelli, Luca , Cantafio, Maria Eugenia Gallo , Romeo, Enrica , Raimondi, Lavinia , Caracciolo, Daniele , Zuccalà, Valeria , Rossi, Marco , Neri, Antonino , Munshi, Nikhil C. , Tagliaferri, Pierosandro and Tassone, Pierfrancesco
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) are still to be investigated. Here, we studied the functional significance and the druggability of the oncogenic lncRNA MALAT1 in MM. Targeting MALAT1 by novel LNA-gapmeR antisense oligonucleotide antagonized MM cell proliferation and triggered...
Alternative Titles
Full title
Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity
Authors, Artists and Contributors
Author / Creator
Stamato, Maria Angelica
Juli, Giada
Morelli, Eugenio
Fulciniti, Mariateresa
Manzoni, Martina
Taiana, Elisa
Agnelli, Luca
Cantafio, Maria Eugenia Gallo
Romeo, Enrica
Raimondi, Lavinia
Caracciolo, Daniele
Zuccalà, Valeria
Rossi, Marco
Neri, Antonino
Munshi, Nikhil C.
Tagliaferri, Pierosandro
Tassone, Pierfrancesco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6127082
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6127082
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-018-0067-3
