Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating...
Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation
About this item
Full title
Author / Creator
Feng, Yan , Guo, Xing , Huang, Xinping , Wu, Manya , Li, Xin , Wu, Shushu and Luo, Xiaoling
Publisher
Greece: Spandidos Publications
Journal title
Language
English
Formats
Publication information
Publisher
Greece: Spandidos Publications
Subjects
More information
Scope and Contents
Contents
Cancer stem cells (CSCs) have been reported to be associated with the recurrence and drug resistance of liver cancer. In the present study, stem cell‑like HepG2 cell spheres were enriched using stem cell conditioned culture medium. As expected, stem‑like HepG2 cell spheres exhibited increased resistance to sorafenib. Metformin, a common drug used t...
Alternative Titles
Full title
Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131649
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6131649
Other Identifiers
ISSN
1791-2997
E-ISSN
1791-3004
DOI
10.3892/mmr.2018.9348
