Mutational signatures associated with tobacco smoking in human cancer
Mutational signatures associated with tobacco smoking in human cancer
About this item
Full title
Author / Creator
Alexandrov, Ludmil B. , Ju, Young Seok , Haase, Kerstin , Van Loo, Peter , Martincorena, Iñigo , Nik-Zainal, Serena , Totoki, Yasushi , Fujimoto, Akihiro , Nakagawa, Hidewaki , Shibata, Tatsuhiro , Campbell, Peter J. , Vineis, Paolo , Phillips, David H. , Stratton, Michael R. and Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which contribute to different extents in different...
Alternative Titles
Full title
Mutational signatures associated with tobacco smoking in human cancer
Authors, Artists and Contributors
Author / Creator
Ju, Young Seok
Haase, Kerstin
Van Loo, Peter
Martincorena, Iñigo
Nik-Zainal, Serena
Totoki, Yasushi
Fujimoto, Akihiro
Nakagawa, Hidewaki
Shibata, Tatsuhiro
Campbell, Peter J.
Vineis, Paolo
Phillips, David H.
Stratton, Michael R.
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6141049
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6141049
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aag0299
