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Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 p...

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 p...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6142274

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

About this item

Full title

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (27), p.E6310-E6318

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The limited host tropism of numerous viruses causing disease in humans remains incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has reemerged in recent years. Here, we demonstrate that ZIKV efficiently infects fibroblasts from humans, great apes, New and Old World monkeys, but not rodents. ZIKV infection in human—but not...

Alternative Titles

Full title

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6142274

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6142274

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1803406115

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