Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
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Author / Creator
Dev, Harveer , Chiang, Ting-Wei Will , Lescale, Chloe , de Krijger, Inge , Martin, Alistair G. , Pilger, Domenic , Coates, Julia , Sczaniecka-Clift, Matylda , Wei, Wenming , Ostermaier, Matthias , Herzog, Mareike , Lam, Jonathan , Shea, Abigail , Demir, Mukerrem , Wu, Qian , Yang, Fengtang , Fu, Beiyuan , Lai, Zhongwu , Balmus, Gabriel , Belotserkovskaya, Rimma , Serra, Violeta , O’Connor, Mark J. , Bruna, Alejandra , Beli, Petra , Pellegrini, Luca , Caldas, Carlos , Deriano, Ludovic , Jacobs, Jacqueline J. L. , Galanty, Yaron and Jackson, Stephen P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISPR–Cas9 synthetic-viability/resistance screens in BRCA1-deficient breast cancer cells treated with PARP inhibitors. We identi...
Alternative Titles
Full title
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
Authors, Artists and Contributors
Author / Creator
Chiang, Ting-Wei Will
Lescale, Chloe
de Krijger, Inge
Martin, Alistair G.
Pilger, Domenic
Coates, Julia
Sczaniecka-Clift, Matylda
Wei, Wenming
Ostermaier, Matthias
Herzog, Mareike
Lam, Jonathan
Shea, Abigail
Demir, Mukerrem
Wu, Qian
Yang, Fengtang
Fu, Beiyuan
Lai, Zhongwu
Balmus, Gabriel
Belotserkovskaya, Rimma
Serra, Violeta
O’Connor, Mark J.
Bruna, Alejandra
Beli, Petra
Pellegrini, Luca
Caldas, Carlos
Deriano, Ludovic
Jacobs, Jacqueline J. L.
Galanty, Yaron
Jackson, Stephen P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6145444
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6145444
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0140-1
