Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic le...
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia
About this item
Full title
Author / Creator
Burns, Melissa A. , Liao, Zi Wei , Yamagata, Natsuko , Pouliot, Gayle P. , Stevenson, Kristen E. , Neuberg, Donna S. , Thorner, Aaron R. , Ducar, Matthew , Silverman, Emily A. , Hunger, Stephen P. , Loh, Mignon L. , Winter, Stuart S. , Dunsmore, Kimberly P. , Wood, Brent , Devidas, Meenakshi , Harris, Marian H. , Silverman, Lewis B. , Sallan, Stephen E. and Gutierrez, Alejandro
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic intervention. Here, we show that Hedgehog pathway muta...
Alternative Titles
Full title
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Liao, Zi Wei
Yamagata, Natsuko
Pouliot, Gayle P.
Stevenson, Kristen E.
Neuberg, Donna S.
Thorner, Aaron R.
Ducar, Matthew
Silverman, Emily A.
Hunger, Stephen P.
Loh, Mignon L.
Winter, Stuart S.
Dunsmore, Kimberly P.
Wood, Brent
Devidas, Meenakshi
Harris, Marian H.
Silverman, Lewis B.
Sallan, Stephen E.
Gutierrez, Alejandro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6148437
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6148437
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-018-0097-x
