Population dynamics of normal human blood inferred from somatic mutations
Population dynamics of normal human blood inferred from somatic mutations
About this item
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Author / Creator
Lee-Six, Henry , Øbro, Nina Friesgaard , Shepherd, Mairi S. , Grossmann, Sebastian , Dawson, Kevin , Belmonte, Miriam , Osborne, Robert J. , Huntly, Brian J. P. , Martincorena, Inigo , Anderson, Elizabeth , O’Neill, Laura , Stratton, Michael R. , Laurenti, Elisa , Green, Anthony R. , Kent, David G. and Campbell, Peter J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and applied population-genetics app...
Alternative Titles
Full title
Population dynamics of normal human blood inferred from somatic mutations
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6163040
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6163040
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0497-0
