BAP1 links metabolic regulation of ferroptosis to tumour suppression
BAP1 links metabolic regulation of ferroptosis to tumour suppression
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Author / Creator
Zhang, Yilei , Shi, Jiejun , Liu, Xiaoguang , Feng, Li , Gong, Zihua , Koppula, Pranavi , Sirohi, Kapil , Li, Xu , Wei, Yongkun , Lee, Hyemin , Zhuang, Li , Chen, Gang , Xiao, Zhen-Dong , Hung, Mien-Chie , Chen, Junjie , Huang, Peng , Li, Wei and Gan, Boyi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (
BAP1
) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here, integrated transcriptomic, epigenomic and cancer genomic analyses...
Alternative Titles
Full title
BAP1 links metabolic regulation of ferroptosis to tumour suppression
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6170713
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6170713
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0178-0
