Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
About this item
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Author / Creator
NN102/SPRINT-MS Trial Investigators , Fox, Robert J , Coffey, Christopher S , Conwit, Robin , Cudkowicz, Merit E , Gleason, Trevis , Goodman, Andrew , Klawiter, Eric C , Matsuda, Kazuko , McGovern, Michelle , Naismith, Robert T , Ashokkumar, Akshata , Barnes, Janel , Ecklund, Dixie , Klingner, Elizabeth , Koepp, Maxine , Long, Jeffrey D , Natarajan, Sneha , Thornell, Brenda , Yankey, Jon , Bermel, Robert A , Debbins, Josef P , Huang, Xuemei , Jagodnik, Patricia , Lowe, Mark J , Nakamura, Kunio , Narayanan, Sridar , Sakaie, Ken E , Thoomukuntla, Bhaskar , Zhou, Xiaopeng , Krieger, Stephen , Alvarez, Enrique , Apperson, Michelle , Bashir, Khurram , Cohen, Bruce A , Coyle, Patricia K , Delgado, Silvia , Dewitt, L. Dana , Flores, Angela , Giesser, Barbara S , Goldman, Myla D , Jubelt, Burk , Lava, Neil , Lynch, Sharon G , Moses, Harold , Ontaneda, Daniel , Perumal, Jai S , Racke, Michael , Repovic, Pavle , Riley, Claire S , Severson, Christopher , Shinnar, Shlomo , Suski, Valerie , Weinstock-Guttman, Bianca , Yadav, Vijayshree and Zabeti, Aram
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
The antiinflammatory small molecule ibudilast was tested in a phase 2 trial in patients with progressive multiple sclerosis. The rate of brain atrophy over 96 weeks was lower with ibudilast than with placebo. Side effects with ibudilast included GI symptoms and depression.
Alternative Titles
Full title
Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
Authors, Artists and Contributors
Author / Creator
Fox, Robert J
Coffey, Christopher S
Conwit, Robin
Cudkowicz, Merit E
Gleason, Trevis
Goodman, Andrew
Klawiter, Eric C
Matsuda, Kazuko
McGovern, Michelle
Naismith, Robert T
Ashokkumar, Akshata
Barnes, Janel
Ecklund, Dixie
Klingner, Elizabeth
Koepp, Maxine
Long, Jeffrey D
Natarajan, Sneha
Thornell, Brenda
Yankey, Jon
Bermel, Robert A
Debbins, Josef P
Huang, Xuemei
Jagodnik, Patricia
Lowe, Mark J
Nakamura, Kunio
Narayanan, Sridar
Sakaie, Ken E
Thoomukuntla, Bhaskar
Zhou, Xiaopeng
Krieger, Stephen
Alvarez, Enrique
Apperson, Michelle
Bashir, Khurram
Cohen, Bruce A
Coyle, Patricia K
Delgado, Silvia
Dewitt, L. Dana
Flores, Angela
Giesser, Barbara S
Goldman, Myla D
Jubelt, Burk
Lava, Neil
Lynch, Sharon G
Moses, Harold
Ontaneda, Daniel
Perumal, Jai S
Racke, Michael
Repovic, Pavle
Riley, Claire S
Severson, Christopher
Shinnar, Shlomo
Suski, Valerie
Weinstock-Guttman, Bianca
Yadav, Vijayshree
Zabeti, Aram
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6172944
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6172944
Other Identifiers
ISSN
0028-4793,1533-4406
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1803583
