Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration...
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
About this item
Full title
Author / Creator
Pujols, Jordi , Peña-Díaz, Samuel , Lázaro, Diana F. , Peccati, Francesca , Pinheiro, Francisca , González, Danilo , Carija, Anita , Navarro, Susanna , Conde-Giménez, María , García, Jesús , Guardiola, Salvador , Giralt, Ernest , Salvatella, Xavier , Sancho, Javier , Sodupe, Mariona , Outeiro, Tiago Fleming , Dalfó, Esther and Ventura, Salvador
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of intracellular protein inclusions, known as Lewy bodies and Lewy neurites, which are mainly composed of α-synuclein. Here, we exploited...
Alternative Titles
Full title
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Authors, Artists and Contributors
Author / Creator
Peña-Díaz, Samuel
Lázaro, Diana F.
Peccati, Francesca
Pinheiro, Francisca
González, Danilo
Carija, Anita
Navarro, Susanna
Conde-Giménez, María
García, Jesús
Guardiola, Salvador
Giralt, Ernest
Salvatella, Xavier
Sancho, Javier
Sodupe, Mariona
Outeiro, Tiago Fleming
Dalfó, Esther
Ventura, Salvador
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6187188
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6187188
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1804198115
