High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial...
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
About this item
Full title
Author / Creator
Sago, Cory D. , Lokugamage, Melissa P. , Paunovska, Kalina , Vanover, Daryll A. , Monaco, Christopher M. , Shah, Nirav N. , Castro, Marielena Gamboa , Anderson, Shannon E. , Rudoltz, Tobi G. , Lando, Gwyneth N. , Tiwari, Pooja Mummilal , Kirschman, Jonathan L. , Willett, Nick , Jang, Young C. , Santangelo, Philip J. , Bryksin, Anton V. and Dahlman, James E.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Dysfunctional endothelium causes more disease than any other cell type. Systemically administered RNA delivery to nonliver tissues remains challenging, in large part because there is no high-throughput method to identify nanoparticles that deliver functional mRNA to cells in vivo. Here we report a system capable of simultaneously quantifying how >1...
Alternative Titles
Full title
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Authors, Artists and Contributors
Author / Creator
Lokugamage, Melissa P.
Paunovska, Kalina
Vanover, Daryll A.
Monaco, Christopher M.
Shah, Nirav N.
Castro, Marielena Gamboa
Anderson, Shannon E.
Rudoltz, Tobi G.
Lando, Gwyneth N.
Tiwari, Pooja Mummilal
Kirschman, Jonathan L.
Willett, Nick
Jang, Young C.
Santangelo, Philip J.
Bryksin, Anton V.
Dahlman, James E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6196543
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6196543
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1811276115
