Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss
Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
The underlying molecular mechanisms of age-related hearing loss (ARHL) in humans and many strains of mice have not been fully characterized. This common age-related disorder is assumed to be closely associated with oxidative stress. Here, we demonstrate that mTORC1 signaling is highly and specifically activated in the cochlear neurosensory epitheli...
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Full title
Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6205401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6205401
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI98058
