CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions
CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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CRISPR-Cas systems not only play key roles in prokaryotic acquired immunity, but can also be adapted as powerful genome editing tools. Understanding the native role of CRISPR-Cas systems in providing adaptive immunity can lead to new CRISPR-based technologies. Here, we develop CRISPRminer, a knowledge base and web server to comprehensively collect and investigate the knowledge of CRISPR-Cas systems and generate instructive annotations, including CRISPR arrays and Cas protein annotation, CRISPR-Cas system classification, self-targeting events detection, microbe–phage interaction inference, and anti-CRISPR annotation. CRISPRminer is user-friendly and freely available at
http://www.microbiome-bigdata.com/CRISPRminer
.
Fan Zhang et al. present CRISPRminer, a comprehensive database for exploring CRISPR-Cas systems in more than 3500 microbial species and a web-server for in-depth data mining. CRISPRminer allows researchers to predict CRISPR-Cas systems and investigate self-targeting CRISPRs, microbe-phage interaction networks, and anti-CRISPR features....
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CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6208339
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6208339
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2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-018-0184-6
