Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in t...
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
About this item
Full title
Author / Creator
Newton, Kim , Dugger, Debra L. , Sengupta-Ghosh, Arundhati , Ferrando, Ronald E. , Chu, Felix , Tao, Janet , Lam, Wendy , Haller, Susan , Chan, Sara , Sa, Susan , Dunlap, Debra , Eastham-Anderson, Jeffrey , Ngu, Hai , Hung, Jeffrey , French, Dorothy M. , Webster, Joshua D. , Bolon, Brad , Liu, Jinfeng , Reja, Rohit , Kummerfeld, Sarah , Chen, Ying-Jiun , Modrusan, Zora , Lewcock, Joseph W. and Dixit, Vishva M.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The E3 ubiquitin ligase CRL4COP1/DET1 is active in the absence of ERK signaling, modifying the transcription factors ETV1, ETV4, ETV5, and c-JUN with polyubiquitin that targets them for proteasomal degradation. Here we show that this posttranslational regulatory mechanism is active in neurons, with ETV5 and c-JUN accumulating within minutes of ERK...
Alternative Titles
Full title
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Authors, Artists and Contributors
Author / Creator
Dugger, Debra L.
Sengupta-Ghosh, Arundhati
Ferrando, Ronald E.
Chu, Felix
Tao, Janet
Lam, Wendy
Haller, Susan
Chan, Sara
Sa, Susan
Dunlap, Debra
Eastham-Anderson, Jeffrey
Ngu, Hai
Hung, Jeffrey
French, Dorothy M.
Webster, Joshua D.
Bolon, Brad
Liu, Jinfeng
Reja, Rohit
Kummerfeld, Sarah
Chen, Ying-Jiun
Modrusan, Zora
Lewcock, Joseph W.
Dixit, Vishva M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6217379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6217379
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1805033115
