pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition i...
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry
About this item
Full title
Author / Creator
Jones, Gemma N. , Rooney, Claire , Griffin, Nicola , Roudier, Martine , Young, Lucy A. , Garcia-Trinidad, Antonio , Hughes, Gareth D. , Whiteaker, Jeffrey R. , Wilson, Zena , Odedra, Rajesh , Zhao, Lei , Ivey, Richard G. , Howat, William J. , Harrington, Elizabeth A. , Barrett, J. Carl , Ramos-Montoya, Antonio , Lau, Alan , Paulovich, Amanda G. , Cadogan, Elaine B. and Pierce, Andrew J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
AZD0156 and AZD6738 are potent and selective inhibitors of ataxia-telangiectasia-kinase (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR), respectively, important sensors/signallers of DNA damage.
Methods
We used multiplexed targeted-mass-spectrometry to select pRAD50(Ser635) as a pharmacodynamic biomarker for AZD01...
Alternative Titles
Full title
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry
Authors, Artists and Contributors
Author / Creator
Rooney, Claire
Griffin, Nicola
Roudier, Martine
Young, Lucy A.
Garcia-Trinidad, Antonio
Hughes, Gareth D.
Whiteaker, Jeffrey R.
Wilson, Zena
Odedra, Rajesh
Zhao, Lei
Ivey, Richard G.
Howat, William J.
Harrington, Elizabeth A.
Barrett, J. Carl
Ramos-Montoya, Antonio
Lau, Alan
Paulovich, Amanda G.
Cadogan, Elaine B.
Pierce, Andrew J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6251026
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6251026
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-018-0286-4
