Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-dens...
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
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Author / Creator
Mahajan, Anubha , Taliun, Daniel , Thurner, Matthias , Robertson, Neil R , Torres, Jason M , Rayner, N William , Steinthorsdottir, Valgerdur , Scott, Robert A , Grarup, Niels , Cook, James P , Schmidt, Ellen M , Wuttke, Matthias , Sarnowski, Chloé , Mägi, Reedik , Nano, Jana , Gieger, Christian , Trompet, Stella , Lecoeur, Cécile , Preuss, Michael , Prins, Bram Peter , Guo, Xiuqing , Bielak, Lawrence F , Bennett, Amanda J , Bork-Jensen, Jette , Brummett, Chad M , Canouil, Mickaël , Eckardt, Kai-Uwe , Fischer, Krista , Kardia, Sharon LR , Kronenberg, Florian , Läll, Kristi , Liu, Ching-Ti , Locke, Adam E , Luan, Jian'an , Ntalla, Ioanna , Nylander, Vibe , Schönherr, Sebastian , Schurmann, Claudia , Yengo, Loïc , Bottinger, Erwin P , Brandslund, Ivan , Christensen, Cramer , Dedoussis, George , Florez, Jose C , ford, Ian , Franco, Oscar H , Frayling, Timothy M , Giedraitis, Vilmantas , Hackinger, Sophie , Hattersley, Andrew T , Herder, Christian , Ikram, M Arfan , Ingelsson, Martin , Jørgensen, Marit E , Jørgensen, Torben , Kriebel, Jennifer , Kuusisto, Johanna , Ligthart, Symen , Lindgren, Cecilia M , Linneberg, Allan , Lyssenko, Valeriya , Mamakou, Vasiliki , Meitinger, Thomas , Mohlke, Karen L , Morris, Andrew D , Nadkarni, Girish , Pankow, James S , Peters, Annette , Sattar, Naveed , Stančáková, Alena , Strauch, Konstantin , Taylor, Kent D , Thorand, Barbara , Thorleifsson, Gudmar , Thorsteinsdottir, Unnur , Tuomilehto, Jaakko , Witte, Daniel R , Dupuis, Josée , Peyser, Patricia A , Zeggini, Eleftheria , Loos, Ruth J F , Froguel, Philippe , Ingelsson, Erik , Lind, Lars , Groop, Leif , Laakso, Markku , Collins, Francis S , Jukema, J Wouter , Palmer, Colin N A , Grallert, Harald , Metspalu, Andres , Dehghan, Abbas , Köttgen, Anna , Abecasis, Goncalo , Meigs, James B , Rotter, Jerome I , Marchini, Jonathan , Pedersen, Oluf and Hansen, Torben
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English
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Scope and Contents
Contents
We aggregated genome-wide genotyping data from 32 European-descent GWAS (74,124 T2D cases, 824,006 controls) imputed to high-density reference panels of >30,000 sequenced haplotypes. Analysis of ˜27M variants (˜21M with minor allele frequency [MAF]<5%), identified 243 genome-wide significant loci (
p
<5x10
-8
; MAF 0.02%-50%; odds ratio...
Alternative Titles
Full title
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Authors, Artists and Contributors
Author / Creator
Taliun, Daniel
Thurner, Matthias
Robertson, Neil R
Torres, Jason M
Rayner, N William
Steinthorsdottir, Valgerdur
Scott, Robert A
Grarup, Niels
Cook, James P
Schmidt, Ellen M
Wuttke, Matthias
Sarnowski, Chloé
Mägi, Reedik
Nano, Jana
Gieger, Christian
Trompet, Stella
Lecoeur, Cécile
Preuss, Michael
Prins, Bram Peter
Guo, Xiuqing
Bielak, Lawrence F
Bennett, Amanda J
Bork-Jensen, Jette
Brummett, Chad M
Canouil, Mickaël
Eckardt, Kai-Uwe
Fischer, Krista
Kardia, Sharon LR
Kronenberg, Florian
Läll, Kristi
Liu, Ching-Ti
Locke, Adam E
Luan, Jian'an
Ntalla, Ioanna
Nylander, Vibe
Schönherr, Sebastian
Schurmann, Claudia
Yengo, Loïc
Bottinger, Erwin P
Brandslund, Ivan
Christensen, Cramer
Dedoussis, George
Florez, Jose C
ford, Ian
Franco, Oscar H
Frayling, Timothy M
Giedraitis, Vilmantas
Hackinger, Sophie
Hattersley, Andrew T
Herder, Christian
Ikram, M Arfan
Ingelsson, Martin
Jørgensen, Marit E
Jørgensen, Torben
Kriebel, Jennifer
Kuusisto, Johanna
Ligthart, Symen
Lindgren, Cecilia M
Linneberg, Allan
Lyssenko, Valeriya
Mamakou, Vasiliki
Meitinger, Thomas
Mohlke, Karen L
Morris, Andrew D
Nadkarni, Girish
Pankow, James S
Peters, Annette
Sattar, Naveed
Stančáková, Alena
Strauch, Konstantin
Taylor, Kent D
Thorand, Barbara
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Tuomilehto, Jaakko
Witte, Daniel R
Dupuis, Josée
Peyser, Patricia A
Zeggini, Eleftheria
Loos, Ruth J F
Froguel, Philippe
Ingelsson, Erik
Lind, Lars
Groop, Leif
Laakso, Markku
Collins, Francis S
Jukema, J Wouter
Palmer, Colin N A
Grallert, Harald
Metspalu, Andres
Dehghan, Abbas
Köttgen, Anna
Abecasis, Goncalo
Meigs, James B
Rotter, Jerome I
Marchini, Jonathan
Pedersen, Oluf
Hansen, Torben
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6287706
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6287706
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0241-6
