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Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6294879

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

About this item

Full title

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (50), p.E11701-E11710

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Cancer immunotherapy has emerged as an effective therapy in a variety of cancers. However, a key challenge in the field is that only a subset of patients who receive immunotherapy exhibit durable response. It has been hypothesized that host genetics influences the inherent immune profiles of patients and may underlie their differential response to...

Alternative Titles

Full title

Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6294879

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6294879

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1804506115

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