Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
About this item
Full title
Author / Creator
Zeid, Rhamy , Lawlor, Matthew A. , Poon, Evon , Reyes, Jaime M. , Fulciniti, Mariateresa , Lopez, Michael A. , Scott, Thomas G. , Nabet, Behnam , Erb, Michael A. , Winter, Georg E. , Jacobson, Zoe , Polaski, Donald R. , Karlin, Kristen L. , Hirsch, Rachel A. , Munshi, Nikhil P. , Westbrook, Thomas F. , Chesler, Louis , Lin, Charles Y. and Bradner, James E.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motifs in an affinity-dependent manner, binding to stro...
Alternative Titles
Full title
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Authors, Artists and Contributors
Author / Creator
Lawlor, Matthew A.
Poon, Evon
Reyes, Jaime M.
Fulciniti, Mariateresa
Lopez, Michael A.
Scott, Thomas G.
Nabet, Behnam
Erb, Michael A.
Winter, Georg E.
Jacobson, Zoe
Polaski, Donald R.
Karlin, Kristen L.
Hirsch, Rachel A.
Munshi, Nikhil P.
Westbrook, Thomas F.
Chesler, Louis
Lin, Charles Y.
Bradner, James E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6310397
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6310397
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0044-9
