TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
About this item
Full title
Author / Creator
Vogler, Thomas O. , Wheeler, Joshua R. , Nguyen, Eric D. , Hughes, Michael P. , Britson, Kyla A. , Lester, Evan , Rao, Bhalchandra , Betta, Nicole Dalla , Whitney, Oscar N. , Ewachiw, Theodore E. , Gomes, Edward , Shorter, James , Lloyd, Thomas E. , Eisenberg, David S. , Taylor, J. Paul , Johnson, Aaron M. , Olwin, Bradley B. and Parker, Roy
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A dominant histopathological feature in neuromuscular diseases, including amyotrophic lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA-binding protein TDP-43. Although rare mutations in
TARDBP
—the gene that encodes TDP-43—that lead to protein misfolding often cause protein aggregation, most patients do not...
Alternative Titles
Full title
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
Authors, Artists and Contributors
Author / Creator
Wheeler, Joshua R.
Nguyen, Eric D.
Hughes, Michael P.
Britson, Kyla A.
Lester, Evan
Rao, Bhalchandra
Betta, Nicole Dalla
Whitney, Oscar N.
Ewachiw, Theodore E.
Gomes, Edward
Shorter, James
Lloyd, Thomas E.
Eisenberg, David S.
Taylor, J. Paul
Johnson, Aaron M.
Olwin, Bradley B.
Parker, Roy
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6324568
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6324568
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0665-2
