µLAS: Sizing of expanded trinucleotide repeats with femtomolar sensitivity in less than 5 minutes
µLAS: Sizing of expanded trinucleotide repeats with femtomolar sensitivity in less than 5 minutes
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
We present µLAS, a lab-on-chip system that concentrates, separates, and detects DNA fragments in a single module. µLAS speeds up DNA size analysis in minutes using femtomolar amounts of amplified DNA. Here we tested the relevance of µLAS for sizing expanded trinucleotide repeats, which cause over 20 different neurological and neuromuscular disorder...
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Full title
µLAS: Sizing of expanded trinucleotide repeats with femtomolar sensitivity in less than 5 minutes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6328573
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6328573
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-36632-5
