Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquiti...
Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1
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Author / Creator
Zhu, Yuekun , Qu, Chao , Hong, Xuehui , Jia, Yanyan , Lin, Meihua , Luo, Yunmei , Lin, Fengqin , Xie, Xiaolong , Xie, Xiaoqi , Huang, Juan , Wu, Qin , Qiu, Xingfeng , Piao, Daxun , Xing, Yanwei , Yu, Tian , Lu, Yuanfu , Huang, Qiang , Yu, Changyin , Jin, Junfei and Zhang, Zhiyong
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role of Trabid in tumors including hepatocellular carcinoma (HCC) and the underlying mechanisms controlling its activity remain poorly understood. Here, we report that Trabid is significantly downregulated...
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Full title
Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6329825
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6329825
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-018-0119-2
