Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIS...
Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib
About this item
Full title
Author / Creator
Nannini, Margherita , Tarantino, Giuseppe , Indio, Valentina , Ravegnini, Gloria , Astolfi, Annalisa , Urbini, Milena , De Leo, Antonio , Santini, Donatella , Ceccarelli, Claudio , Gruppioni, Elisa , Altimari, Annalisa , Castellucci, Paolo , Fanti, Stefano , Di Scioscio, Valerio , Saponara, Maristella , Gatto, Lidia , Pession, Andrea , Martelli, Pier Luigi , Casadio, Rita and Pantaleo, Maria Abbondanza
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in approximately 5–7% of gastrointestinal stromal tumours (GIST). Over half of all PDGFRA mutations are represented by the substitution at position 842 in the A-loop of an aspartic acid (D) with a valine (V), recognized as D842V, conferring primary resistance to imatinib
in v...
Alternative Titles
Full title
Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib
Authors, Artists and Contributors
Author / Creator
Tarantino, Giuseppe
Indio, Valentina
Ravegnini, Gloria
Astolfi, Annalisa
Urbini, Milena
De Leo, Antonio
Santini, Donatella
Ceccarelli, Claudio
Gruppioni, Elisa
Altimari, Annalisa
Castellucci, Paolo
Fanti, Stefano
Di Scioscio, Valerio
Saponara, Maristella
Gatto, Lidia
Pession, Andrea
Martelli, Pier Luigi
Casadio, Rita
Pantaleo, Maria Abbondanza
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6379366
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6379366
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-38028-x
