Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-e...
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Macrophages enforce antitumor immunity by engulfing and killing tumor cells. Although these functions are determined by a balance of stimulatory and inhibitory signals, the role of macrophage metabolism is unknown. Here, we study the capacity of macrophages to circumvent inhibitory activity mediated by CD47 on cancer cells. We show that stimulation...
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Full title
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6380920
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6380920
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0292-y
