Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
About this item
Full title
Author / Creator
Kazuki, Yasuhiro , Kobayashi, Kaoru , Hirabayashi, Masumi , Abe, Satoshi , Kajitani, Naoyo , Kazuki, Kanako , Takehara, Shoko , Takiguchi, Masato , Satoh, Daisuke , Kuze, Jiro , Sakuma, Tetsushi , Kaneko, Takehito , Mashimo, Tomoji , Osamura, Minori , Hashimoto, Mari , Wakatsuki, Riko , Hirashima, Rika , Fujiwara, Ryoichi , Deguchi, Tsuneo , Kurihara, Atsushi , Tsukazaki, Yasuko , Senda, Naoto , Yamamoto, Takashi , Scheer, Nico and Oshimura, Mitsuo
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Although “genomically” humanized animals are invaluable tools for generating human disease models as well as for biomedical research, their development has been mainly restricted to mice via established transgenic-based and embryonic stem cell-based technologies. Since rats are widely used for studying human disease and for drug efficacy and toxici...
Alternative Titles
Full title
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Authors, Artists and Contributors
Author / Creator
Kobayashi, Kaoru
Hirabayashi, Masumi
Abe, Satoshi
Kajitani, Naoyo
Kazuki, Kanako
Takehara, Shoko
Takiguchi, Masato
Satoh, Daisuke
Kuze, Jiro
Sakuma, Tetsushi
Kaneko, Takehito
Mashimo, Tomoji
Osamura, Minori
Hashimoto, Mari
Wakatsuki, Riko
Hirashima, Rika
Fujiwara, Ryoichi
Deguchi, Tsuneo
Kurihara, Atsushi
Tsukazaki, Yasuko
Senda, Naoto
Yamamoto, Takashi
Scheer, Nico
Oshimura, Mitsuo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6386724
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1808255116
