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MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391107

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

About this item

Full title

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2019-03, Vol.129 (3), p.1015-1029

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

MAPK4 is an atypical MAPK. Currently, little is known about its physiological function and involvement in diseases, including cancer. A comprehensive analysis of 8887 gene expression profiles in The Cancer Genome Atlas (TCGA) revealed that MAPK4 overexpression correlates with decreased overall survival, with particularly marked survival effects in...

Alternative Titles

Full title

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391107

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391107

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI97712

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