Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fra...
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
About this item
Full title
Author / Creator
Ehmann, D. , Wendler, J. , Koeninger, L. , Larsen, I. S. , Klag, T. , Berger, J. , Marette, A. , Schaller, M. , Stange, E. F. , Malek, N. P. , Jensen, B. A. H. and Wehkamp, J.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control microbiota composition and play a key role in intestinal barrier function and homeostasis. Dynamic conditions in the local microenvironment, such as pH and redox potential, significantly affect the antimicrobial spectrum. In contrast to oxidized peptides, some redu...
Alternative Titles
Full title
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6397583
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6397583
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1817376116
