Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
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Author / Creator
Parhizkar, Samira , Arzberger, Thomas , Brendel, Matthias , Kleinberger, Gernot , Deussing, Maximilian , Focke, Carola , Nuscher, Brigitte , Xiong, Monica , Ghasemigharagoz, Alireza , Katzmarski, Natalie , Krasemann, Susanne , Lichtenthaler, Stefan F. , Müller, Stephan A. , Colombo, Alessio , Monasor, Laura Sebastian , Tahirovic, Sabina , Herms, Jochen , Willem, Michael , Pettkus, Nadine , Butovsky, Oleg , Bartenstein, Peter , Edbauer, Dieter , Rominger, Axel , Ertürk, Ali , Grathwohl, Stefan A. , Neher, Jonas J. , Holtzman, David M. , Meyer-Luehmann, Melanie and Haass, Christian
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Coding variants in the triggering receptor expressed on myeloid cells 2 (
TREM2
) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is accompanied by decreased microglial clustering around newly seeded plaques and reduced plaqu...
Alternative Titles
Full title
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Authors, Artists and Contributors
Author / Creator
Arzberger, Thomas
Brendel, Matthias
Kleinberger, Gernot
Deussing, Maximilian
Focke, Carola
Nuscher, Brigitte
Xiong, Monica
Ghasemigharagoz, Alireza
Katzmarski, Natalie
Krasemann, Susanne
Lichtenthaler, Stefan F.
Müller, Stephan A.
Colombo, Alessio
Monasor, Laura Sebastian
Tahirovic, Sabina
Herms, Jochen
Willem, Michael
Pettkus, Nadine
Butovsky, Oleg
Bartenstein, Peter
Edbauer, Dieter
Rominger, Axel
Ertürk, Ali
Grathwohl, Stefan A.
Neher, Jonas J.
Holtzman, David M.
Meyer-Luehmann, Melanie
Haass, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6417433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6417433
Other Identifiers
ISSN
1097-6256,1546-1726
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0296-9
