Effects of the potassium‐sparing diuretic amiloride on chemotherapy response in canine osteosarcoma...
Effects of the potassium‐sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells
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Author / Creator
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Background
Osteosarcoma (OSA) is a common bone tumor of mesenchymal origin in dogs. Chemotherapy delays metastasis, yet most dogs die of this disease within 1 year of diagnosis. The high metabolic demand of cancer cells promotes proton pump upregulation, leading to acidification of the tumor microenvironment and chemoresistance. The potassium‐sp...
Alternative Titles
Full title
Effects of the potassium‐sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6430882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6430882
Other Identifiers
ISSN
0891-6640
E-ISSN
1939-1676
DOI
10.1111/jvim.15382
