Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated hum...
Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Priming haematopoietic stem/progenitor cells (HSPCs)
in vitro
with specific chromatin modifying agents and cytokines under serum-free-conditions significantly enhances engraftable HSC numbers. We extend these studies by culturing human CD133+ HSPCs on nanofibre scaffolds to mimic the niche for 5-days with the HDAC inhibitor Scriptaid and cyto...
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Full title
Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6438964
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6438964
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-41803-z
