DNA·RNA triple helix formation can function as a cis-acting regulatory mechanism at the human β-glob...
DNA·RNA triple helix formation can function as a cis-acting regulatory mechanism at the human β-globin locus
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
We have identified regulatory mechanisms in which an RNA transcript forms a DNA duplex·RNA triple helix with a gene or one of its regulatory elements, suggesting potential auto-regulatory mechanisms in vivo. We describe an interaction at the human β-globin locus, in which an RNA segment embedded in the second intron of the β-globin gene forms a DNA...
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Full title
DNA·RNA triple helix formation can function as a cis-acting regulatory mechanism at the human β-globin locus
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6442552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6442552
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1900107116
