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A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444936

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

About this item

Full title

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2018-10, Vol.562 (7728), p.600-604

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of enzymes
1
,
2
, and regulate cellular functions such as metabolism
3

5
an...

Alternative Titles

Full title

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444936

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444936

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-018-0622-0

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