A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of enzymes
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,
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, and regulate cellular functions such as metabolism
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–
5
an...
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Full title
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444936
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6444936
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0622-0