Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse mode...
Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain. Using transgenic or viral approaches, we characterized in mice the effects of TYROBP...
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Full title
Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6447470
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6447470
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-018-0258-3
